Cullen's sign and Grey Turner's sign are associated with which condition?

Cullen's sign and Grey Turner's sign are both indicative of bleeding in the abdominal cavity and are commonly associated with acute pancreatitis. Cullen's sign appears as periumbilical ecchymosis, while Grey Turner's sign manifests as flank ecchymosis. These signs suggest that there is retroperitoneal hemorrhage, which can be seen in cases of acute inflammation of the pancreas, often due to conditions such as gallstones or alcohol consumption.

In the context of acute pancreatitis, these signs become apparent due to the release of proteolytic enzymes from the inflamed pancreas, leading to local tissue damage and bleeding. The presence of these signs can help healthcare providers assess the severity of the condition and consider potential complications, such as necrotizing pancreatitis or hemorrhagic pancreatitis.

While signs and symptoms might overlap in chronic pancreatitis, cirrhosis, or liver cancer, Cullen's and Grey Turner's signs are specifically linked to the acute inflammatory process associated with acute pancreatitis, making it the most appropriate choice for this question.