In which patient population should bupropion NOT be prescribed?

Bupropion should not be prescribed to patients with a history of seizures due to its potential to lower the seizure threshold. Bupropion acts as a stimulant and can increase the risk of seizures, particularly in those who have a predisposition due to a history of seizure disorders or certain other risk factors. The risk associated with prescribing bupropion in this patient population is well-established, making it essential for healthcare providers to avoid this medication for patients who are known to have seizures.

In contrast, while there may be considerations for its use in various populations, bupropion may still be prescribed cautiously in patients with anxiety disorders, ADHD, and chronic fatigue syndrome, depending on individual circumstances and accompanying symptoms. These conditions do not inherently present the same level of risk for seizures as a direct history of seizure disorders does.