What clinical manifestation is commonly seen in patients with hypercalcemia?

Hypercalcemia, an elevated level of calcium in the blood, commonly leads to a variety of clinical manifestations, often summarized by the phrase "stones, bones, groans, and psychiatric overtones." The term "psychic moans" relates to the neuropsychiatric symptoms that can arise from hypercalcemia, which may include confusion, depression, and lethargy. This term captures the mental disturbances that occur due to the effects of high calcium levels on the central nervous system.

The other options, while they may be associated with various medical conditions, are not typical manifestations of hypercalcemia. Skin rashes may indicate allergic reactions or infections but are not specifically linked to hypercalcemia. Jaundice often signals liver dysfunction or hemolysis, and edema is a sign of fluid retention commonly associated with heart or kidney issues. Therefore, the most directly related clinical manifestation of hypercalcemia is indeed the psychiatric symptoms, represented by "psychic moans."