What is commonly used in the treatment of H. pylori infection?

The commonly used treatment for H. pylori infection is triple therapy, which consists of Clarithromycin, Amoxicillin, and a Proton Pump Inhibitor (PPI). This regimen is effective because it combines two antibiotics that target the bacteria—the combination helps prevent resistance, ensuring a higher rate of eradication. The PPI reduces gastric acid production, which not only alleviates ulcer symptoms but also enhances antibiotic efficacy by creating a less acidic environment in the stomach, allowing for better absorption of the antibiotics.

The triple therapy approach typically lasts 10 to 14 days and is recommended because H. pylori can be difficult to eradicate with less aggressive treatments. By using a combination of medications, this regimen increases the chance of success and decreases the likelihood of treatment failure, which is critical given that H. pylori is linked to the development of peptic ulcers and gastric cancer.