What is the first-line treatment for cluster headaches?

The first-line treatment for cluster headaches is 100% oxygen therapy. This approach is highly effective and is often utilized due to its rapid action in alleviating headache symptoms. In cluster headache episodes, inhaling pure oxygen can lead to significant relief within minutes for many patients. This is thought to work by inducing vasoconstriction and altering the levels of carbon dioxide in the blood, thus providing quick symptomatic relief.

Other treatment options exist, but they do not serve as first-line therapies for acute cluster headache attacks. High-dose NSAIDs and triptans are commonly used in various types of headaches, but they are not typically the primary choices for cluster headaches. Dopamine blockers may have some utility in headache management but are not specifically indicated for cluster headaches. As such, oxygen therapy remains the most rapid and efficacious option for individuals experiencing this type of headache episode.