What is the preferred first-line treatment for generalized anxiety disorder?

The preferred first-line treatment for generalized anxiety disorder (GAD) is selective serotonin reuptake inhibitors (SSRIs). SSRIs are well-researched and have been demonstrated to effectively reduce the symptoms of anxiety by increasing serotonin levels in the brain, which can lead to improved mood and reduced anxiety. They are preferred due to their safety profile, lower risk of dependency, and long-lasting effects compared to other medications.

Benzodiazepines, while they can provide quick relief from acute anxiety symptoms, are generally not recommended for long-term management of GAD due to their potential for dependency and tolerance.

Tricyclic antidepressants (TCAs) may be effective but are typically not the first choice because they can have more side effects and a higher risk profile compared to SSRIs.

Buspirone is another option for treating anxiety, but it is often considered second-line treatment as it may take longer to achieve its effects and is generally less effective than SSRIs for GAD.

Thus, SSRIs are favored for their efficacy, safety, and favorable side effect profile, making them the most appropriate first-line treatment for managing generalized anxiety disorder.