What serological markers indicate a resolved hepatitis B infection?

A resolved hepatitis B infection is indicated by specific serological markers in the patient's blood. The presence of positive Hepatitis B surface antibody (HBsAb or anti-HBs) along with a negative Hepatitis B surface antigen (HBsAg) is the hallmark of a resolved infection.

When HBsAg is negative, this suggests that the virus is no longer present in the bloodstream. The presence of HBsAb indicates that the individual has developed an immune response and has cleared the virus. This immune response typically occurs after an acute infection or after vaccination against hepatitis B.

In contrast, when HBsAg is positive along with negative HBsAb, it indicates an active hepatitis B infection, which is not synonymous with resolution. Thus, the combination of negative HBsAg and positive HBsAb clearly signifies that the infection has resolved, with the individual likely now immune to future infection.

Understanding these markers is critical for diagnosing and managing hepatitis B infections.