What syndrome is characterized by asymptomatic jaundice, increased indirect bilirubin, and normal liver function tests due to a deficiency of glucuronosyltransferase?

Gilbert syndrome is characterized by an increase in indirect (unconjugated) bilirubin levels due to a deficiency of the enzyme glucuronosyltransferase, which is responsible for the conjugation of bilirubin in the liver. Individuals with Gilbert syndrome often exhibit asymptomatic jaundice, particularly during periods of stress, fasting, or illness, but have normal liver function tests, indicating that their liver is functioning properly despite the bilirubin elevation.

The enzyme deficiency in Gilbert syndrome is typically mild and does not lead to significant liver dysfunction or other serious complications, which is why liver function tests remain normal. The jaundice observed in this condition is often benign and does not require treatment.

Other options provided relate to different conditions. For example, Dubin-Johnson syndrome involves conjugated hyperbilirubinemia along with abnormal liver function tests due to the liver's inability to excrete conjugated bilirubin. Crigler-Najjar syndrome is more severe, presenting with high levels of indirect bilirubin and associated risks of kernicterus, while Budd-Chiari syndrome is a hepatic venous occlusion that leads to significant liver dysfunction and related symptoms. Therefore, Gilbert syndrome stands out due to its mild, asymptomatic nature and specific biochemical