Which antibody is often found positive in Crohn’s disease?

The presence of anti-Saccharomyces cerevisiae antibodies (ASCA) is specifically associated with Crohn’s disease. ASCA are antibodies directed against the yeast Saccharomyces cerevisiae, and their positivity can help differentiate Crohn's disease from other inflammatory bowel diseases, particularly ulcerative colitis. Elevated levels of ASCA are particularly noted in patients with Crohn's disease, and their presence can be an important biomarker in the diagnosis and management of this condition.

In contrast, antinuclear antibodies (ANA) are more commonly associated with autoimmune disorders such as lupus and do not specifically point to inflammatory bowel diseases. Perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) are often found in ulcerative colitis, not Crohn's disease, making them less relevant in this context. Anti-dsDNA antibodies are primarily associated with systemic lupus erythematosus and are not linked to inflammatory bowel diseases.

Thus, ASCA serves as a significant marker in identifying Crohn's disease, making it the correct answer in this scenario.