Which antidepressants are known to potentially cause QT prolongation?

The correct understanding of which antidepressants can cause QT prolongation includes both SSRIs and SNRIs, as well as tricyclic antidepressants (TCAs) and even some other types of antidepressants. While SSRIs and SNRIs are commonly prescribed and have fewer side effects, certain medications within these classes, particularly citalopram and escitalopram from the SSRI category, are known to be associated with an increased risk of QT prolongation.

The answer indicating that all antidepressants except combined SSRIs and MAOIs can potentially cause QT prolongation effectively covers a broader range of medications. It is important to recognize that this potential risk is often dose-dependent, with the highest risks observed with TCAs, like amitriptyline and imipramine.

Many cases of QT prolongation can also be exacerbated by co-administration of other medications, electrolyte imbalances, or underlying cardiovascular conditions. Thus, the correct answer highlights the importance of monitoring all antidepressants closely while acknowledging that certain combinations, such as with MAOIs, may increase this risk.