Which viral infection is associated with Hodgkin's lymphoma through its effect on B cells?

Epstein-Barr Virus (EBV) is well-established as being associated with Hodgkin's lymphoma due to its effects on B cells. EBV, a member of the herpesvirus family, infects B lymphocytes and can lead to their proliferation and transformation. The virus has been shown to induce the expression of certain proteins that can promote the growth of B cells and inhibit apoptosis, which means infected cells are less likely to undergo programmed cell death.

This particular interaction between EBV and B cells is significant because Hodgkin's lymphoma is a type of cancer that originates in these immune cells. The presence of EBV in Reed-Sternberg cells, the characteristic cells found in Hodgkin’s lymphoma, supports the strong association between the virus and the disease.

While other viruses, such as HIV and HPV, have their associations with different cancers, they do not specifically have the same direct link to Hodgkin's lymphoma as EBV. HIV, for instance, is more commonly associated with a range of other malignancies due to its overall immunosuppressive effect, while HPV is associated primarily with cervical and certain head and neck cancers. Herpes Simplex Virus is not typically linked to any form of lymphoma. Thus, the specific mechanism by which